
Simon J. Laplante, M.D.
Principal Investigator
Mayo Clinic
Simon J. Laplante, M.D., is a board-certified surgeon in the Division of Metabolic and Abdominal Wall Reconstructive Surgery at Mayo Clinic in Rochester, Minnesota. His work focuses on translating surgical artificial intelligence, computer vision, simulation, and augmented reality into practical tools that improve surgical safety, guidance, coaching, education, and quality improvement. With advanced training in minimally invasive, bariatric, gastrointestinal, and abdominal wall reconstructive surgery, Dr. Laplante combines clinical expertise with rigorous validation of AI systems for real-world surgical decision support and performance assessment.
Featured projects
Selected AI talks & education
When Big AI Meets Next-Generation Robotics: Toward the True Definition of Intelligent Surgical Robots
Simon J. Laplante, M.D.
ASMBS Annual Meeting / San Antonio, Texas
Dr. Laplante delivered a talk on the intersection of large-scale AI and next-generation robotics toward intelligent surgical robots.
Quantum Computing: Solving Complex Surgical Data Challenges
Simon J. Laplante, M.D.
ASMBS Annual Meeting / San Antonio, Texas
Dr. Laplante delivered a talk on quantum computing and its potential role in solving complex surgical data challenges.
Tomorrow's Tools in Use Today: AI, Robotics, Quantum and the Digital OR
Simon J. Laplante, M.D.
ASMBS Annual Meeting / San Antonio, Texas
Dr. Laplante served as director/moderator for a session focused on AI, robotics, quantum computing, and the digital operating room.
AI in Medicine and Surgery: From Basic Concepts to Impact on Clinical Care
Simon J. Laplante, M.D.
George Washington University / Washington, DC
Dr. Laplante delivered an invited lecture on AI in medicine and surgery, from basic concepts to impact on clinical care.
Recent mentions

A-STAR Lab Represents Mayo Clinic at the 2026 ASMBS Annual Meeting
A-STAR Lab represented Mayo Clinic at the 2026 ASMBS Annual Meeting in San Antonio.
Read full story
A-STAR Lab Attends the 2026 SAGES Annual Meeting
Dr. Simon J. Laplante and Dr. Abdulrahman Alomar represented A-STAR Lab at the 2026 SAGES Annual Meeting.
Read full storyDr. Simon Laplante Featured in ASMBS Webinar on AI in Surgery
Dr. Simon J. Laplante appeared as a guest panelist in an ASMBS Bariatric Happy Hour webinar on AI in surgery.
Read full story